THE FEATURES OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE INFLUENCE ON THE PREGNANCY COMPLICATIONS DEVELOPMENT


 In recent years, the prevalence of chronic obstructive pulmonary disease (COPD) has been increasingly observed among women, which is one reasons for higher interest scientists in influence COPD on pregnant woman.
 The aim our study was to establish features development pregnancy complications women with COPD.
 Materials and methods. 77 clinically instrumentally verified signs were examined divided into 2 subgroups depending degree bronchial obstruction: IA - 43 FEV1≥80%, IB 34 FEV1 50-79%. control group consisted 27 healthy women. cytokine profile determined a correlational interaction obstruction frequency obstetric perinatal established.
 results. Our analysis indicators at stage mild moderate showed characteristic reliable increase level pro-inflammatory cytokines (IL-1β, IL-6) simultaneous decrease anti-inflammatory IL-10 (p≤0.05).
 We established that an also associated detection such childbirth as anemia, respectively, by 3.1 times, threatened premature birth 9 preeclampsia 7 placental dysfunction 3.4 intrauterine growth restriction 8 3.5 rupture membranes during labor 4 fetal distress 3 times compared group.
 Conclusions. characterized systemic disturbances balance accompanied significant complications, depends obstruction.